“We are facing an opioid epidemic — a public health crisis — and we must take all necessary steps to reduce the scope of opioid misuse and abuse,” FDA Commissioner Dr. Scott Gottlieb said. “We will continue to take regulatory steps when we see situations where an opioid product’s risks outweigh its benefits, not only for its intended patient population but also in regard to its potential for misuse and abuse.”
“My comment is ‘wow,’ ” said Dr. Andrew Kolodny, co-director of opioid policy research at the Heller School for Social Policy and Management at Brandeis University. “This is pretty exciting. This is big news.”
Though it is a “good sign” for the fight against opioid abuse, he said, “Opana is not the only one that needs to come off the market.”
Endo had tried to make it harder for addicts to use Opana ER by making it with a coating that made it hard to crush. The medication is intended to release over time, but addicts had been crushing it to get a massive high all at once.
The FDA said it made its latest decision based on a review of all post-market data, which suggested that when the company reformulated the medication, people were injecting it more than they were snorting it. This method of delivery also caused a serious outbreak of hepatitis C and a serious blood disorder, according to the agency.
Thursday’s announcement followed a March vote from an independent group of experts, brought together by the FDA, who voted 18-8 that the benefits of reformulation no longer outweighed the risks.
Endo has had other issues with the FDA and the drug. When the company submitted its reformulated version to the FDA in 2012, the agency decided the data weren’t strong enough to show that it could “meaningfully reduce abuse,” and the agency denied a request to include a label that would describe its reformulation as having abuse-deterrent properties.
Endo is reviewing the FDA’s request and evaluating all its options “as we determine the appropriate path forward,” it said in a statement.
“While the benefits of opioids in treating and managing pain are widely recognized, the misuse and abuse of these products have increased greatly in the U.S. As a pharmaceutical company with a demonstrated commitment to the improvement of pain management, Endo feels a strong sense of responsibility to improve the care of pain for patients while at the same time taking comprehensive steps to minimize the potential misuse of its products. Despite the FDA’s request to withdraw Opana ER from the market, this request does not indicate uncertainty with the product’s safety or efficacy when taken as prescribed. Endo remains confident in the body of evidence established through clinical research demonstrating that Opana ER has a favorable risk-benefit profile when used as intended in appropriate patients.”
CNN’s Nadia Kounang contributed to this report.